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Teprotumumab
CAS No. : 1036734-93-6
Biological Activity：Teprotumumab is an IGF-1 receptor (IGF-1R) blocking human monoclonal antibody. Teprotumumab binds to the ligand binding extracellular α-subunit domain of IGF-1R. Teprotumumab inhibits TSH and IGF-1 action in fibrocytes. Teprotumumab attenuates TSH-dependent IL-6 and IL-8 expression and Akt phosphorylation. Teprotumumab can be used for thyroid-associated ophthalmopathy research.
Research Area：Endocrinology
Targets：TSH Receptor|IGF-1R
Related Small Molecules:NCGC00229600;AZ7550 Mesylate;Picropodophyllotoxin-d6;Chromeceptin;I-OMe-Tyrphostin AG 538;Ganitumab;GSK1838705A;AG1024;Xentuzumab;IGF-I (24-41);IGF-I (30-41) (TFA);Robatumumab;Org41841;D3-βArr;BMS-754807;GSK1904529A;NVP-ADW742;XL228;Linsitinib-d3;BMS-536924;NVP-TAE 226;IGF-1R inhibitor-2;NVP-AEW541;NBI-31772;Figitumumab
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