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BMS-191095
CAS No. : 166095-21-2
Biological Activity：BMS-191095 is an activators of mitochondrial ATP-sensitive potassium (mitoKATP) channels.
Target: potassium channel
in vitro: BMS-191095 induces mitochondrial-depolarization and vasodilation. BMS-191095 elicites a dose-dependent vasodilation in endothelium denuded cerebral arteries with 8.1 ± 2.3%, 31.6 ± 2.1%, and 39.5 ± 3.2% relaxation in response to 10, 50, and 100 μM, respectively.
in vivo: In normal rats, BMS-191095-induced vasodilation was mediated by mitochondrial depolarization and calcium sparks generation in VSM and was reduced by inhibition of BKCa channels.
Research Area：Metabolic Disease
Targets：Potassium Channel
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