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Jatrorrhizine hydroxide
CAS No. : 483-43-2
Biological Activity：Jatrorrhizine hydroxide is an alkaloid isolated from Coptis chinensis with neuroprotective, antimicrobial, antiplasmodial and antioxidant activities. Jatrorrhizine hydroxide is a potent and orally active inhibitor of AChE (IC50=872 nM) over >115-fold selectivity for BuChE[2]. Jatrorrhizine hydroxide reduces uptake of serotonin (5-HT) and norepinephrine (NE) via inhibition of uptake-2 transporters[3].
Research Area：Inflammation/Immunology|Neurological Disease
Targets：5-HT Receptor|Cholinesterase (ChE)|Bacterial
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