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SBI-797812

CAS No. : 2237268-08-3

Biological Activity：SBI-797812 is an orally active nicotinamide phosphoribosyltransferase (NAMPT) activator. SBI-797812 shifts NAMPT to NMN formation, increases NAMPT affinity for ATP, stabilizes phosphorylated NAMPT, promotes consumption of the pyrophosphate by-product, and blunts feedback inhibition by NAD⁺. SBI-797812 increases intracellular nicotinamide mononucleotide (NMN) and elevates liver NAD⁺ in mice^[2].

Research Area：Metabolic Disease

Targets：NAMPT

Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Covalent Screening Library;Orally Active Compound Library;Targeted Diversity Library;

Related Small Molecules:Teglarinad chloride;CB 300919;GNE-617;NAMPT inhibitor-linker 2;NAMPT degrader-1;Nampt-IN-8;Nampt-IN-3;Nampt-IN-10 TFA;Nampt-IN-7;LB-60-OF61;Nampt-IN-5;CB30865;GPP78;NAT;Nampt-IN-1;LB-60-OF61 hydrochloride;STF-118804;OT-82;CHS-828;Nampt-IN-9;(E)-Daporinad;GNE-618

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