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Pactimibe sulfate
CAS No. : 608510-47-0
Biological Activity：Pactimibe sulfate (CS-505) is a dual ACAT1/2 inhibitor with IC50s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits ACAT with IC50s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively. Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a Ki value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC50 of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity[2].
Research Area：Cardiovascular Disease
Targets：Acyltransferase
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Clinical Compound Library;Drug Repurposing Compound Library;Anti-Cardiovascular Disease Compound Library;Orally Active Compound Library;Lipid Metabolism Compound Library ;Human Metabolite Library;
Related Small Molecules:RP-64477;Enniatin A;IWP-12;ABT-046;PF-04620110;ACAT-IN-5;TP-020;Diacylglycerol acyltransferase inhibitor-1;JNJ-DGAT2-A;DGAT-1 inhibitor 2;Lateritin;OSMI-3;Avasimibe;Nevanimibe hydrochloride;FCE 28654;YM17E;RP 70676;ACAT-IN-3;Pactimibe;Pradigastat;CP-113818;VULM 1457;A 922500;ACAT-IN-6;AZD3988;T863;PF-06471553;ESI-05;Fumonisin B1
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