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EGFR-IN-57

CAS No. : 2492382-37-1

Biological Activity：EGFR-IN-57 (Compound 25a) is a potent, orally active EGFR-TK inhibitor with an IC₅₀ of 0.054 µM. EGFR-IN-57 also inhibits VEGFR-2, CK2α, topoisomerase IIβ and tubulin polymerization with IC₅₀ values of 0.087, 0.171, 0.13 and 3.61 µM, respectively. EGFR-IN-57 induces cell cycle arrest at G2/M and pre-G1 phases. EGFR-IN-57 induces cancer cell apoptosis.

Research Area：Cancer

Targets：EGFR|Topoisomerase|Microtubule/Tubulin|Casein Kinase|VEGFR|Apoptosis

Related Small Molecules:Physalin A;Bomedemstat ditosylate;(Z)-FeCP-oxindole;Gepotidacin;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Umbralisib hydrochloride;Tirbanibulin dihydrochloride;NSC81111;BJE6-106;Dinaciclib;VEGFR-2-IN-24;pp60 (v-SRC) Autophosphorylation Site, Phosphorylated;Ecteinascidin 770;MDM2-p53-IN-15;BMS-690514;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8

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