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AChE-IN-12

CAS No. : 2764664-52-8

Biological Activity：AChE-IN-12 is a potent and blood-brain barrier (BBB) penetrant acetylcholinesterase (AChE) with IC₅₀s of 0.41 μM and 1.88 μM for rat AChE and electric eel AChE. AChE-IN-12 is also a good antioxidant (ORAC = 3.3 eq), selective metal chelator and huMAO-B inhibitor (IC₅₀ = 8.8 µM). AChE-IN-12 has remarkable inhibition of self- and Cu²⁺-induced Aβ_1-42 aggregation, as well as exhibits a good neuroprotective effect. AChE-IN-12 can be used for researching Alzheimer’s disease.

Research Area：Neurological Disease

Targets：Monoamine Oxidase|Amyloid-β|Cholinesterase (ChE)

Related Small Molecules:β-Amyloid (13-27);Saikosaponin C;PXS-4728A;β-Amyloid (1-42), (rat/mouse) (TFA);Piperilate;β-Amyloid (12-28) (TFA);BuChE-IN-5;Hypericin;Ginsenoside Rg1;MDR-1339;AChE/BChE-IN-10;Simtuzumab;SSAO inhibitor-1;Timosaponin AIII;Trimyristin;AChE-IN-10;Isoimperatorin;Pseudocoptisine chloride;Itopride-d6 hydrochloride;β-Amyloid (11-22);Sinapine thiocyanate;sEH/AChE-IN-1;AChE-IN-11;20(S)-Ginsenoside Rg3;β-Amyloid (31-35)

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