For research use only. We do not sell to patients.
PP-C8
Biological Activity：PP-C8 is a potent and selective PROTAC CDK12-Cyclin K degrader. PP-C8 induces CDK12-Cyclin K degradation with DC50s of 416 and 412 nM for CDK12 and Cyclin K, respectively. PP-C8 demonstrates profound synergistic antiproliferative effects with PARP inhibitor in triple-negative breast cancer (TNBC).
Research Area：Cancer
Targets：CDK|PROTACs
Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;Dinaciclib;SNS-032;CC-671;PROTAC VEGFR-2 degrader-2;(E/Z)-Zotiraciclib;dTAGV-1-NEG;CCT367766 formic;CDK1-IN-4;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;T025;HDAC6 degrader-1;Flavopiridol;CDK8-IN-3;PROTAC Axl Degrader 2;PhosTAC7;CDK9-IN-12;MS98;FLT3/CDK4-IN-1;GFB-12811;GSK 3 Inhibitor IX;JPS014;Eciruciclib;PROTAC PARP1 degrader;MD-224;CDK-IN-6
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
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Structurally and synthetically diverse biologically active compounds；
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