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NLRP3-IN-8

Biological Activity：NLRP3-IN-8 (compound 27) is an orally active, directly binding NLRP3 inflammasome inhibitor with an IC₅₀ value of 1.23 μM against IL-1 β. NLRP3-IN-8 has good metabolic stability to liver microsomes (t_1/2 = 138.63 min), and has almost no toxicity (against L02: IC₅₀ > 100 μM).

Research Area：Inflammation/Immunology

Targets：NOD-like Receptor (NLR)

Related Small Molecules:MCC950;Dapansutrile;NOD-IN-1;NLRP3-IN-4;NLRP3-IN-12;Nigericin;NLRP3-IN-5;β-Aminoarteether;GSK717;NLRP3-IN-NBC6;Selnoflast;NOD1/2 antagonist-1;BMS-986299;NDT-30805;Licochalcone B;Emlenoflast sodium;AMS-17;NLRP3-IN-6;CY-09;NLRP3/AIM2-IN-1;Muscone;INF4E;NLRP3-IN-2

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