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2BAct

CAS No. : 2143542-28-1

Biological Activity：2BAct is a highly selective, and orally active eIF2B (eukaryotic initiation factor 2B) activator with an EC₅₀ of 33 nM. 2BAct prevents neurological defects caused by a chronic integrated stress response. 2BAct is able to penetrate the central nervous system (CNS). 2BAct displays improved solubility and pharmacokinetics relative to eIF2B activator ISRIB (HY-12495).

Research Area：Neurological Disease

Targets：Eukaryotic Initiation Factor (eIF)

Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;CNS-Penetrant Compound Library;Anti-Aging Compound Library;Orally Active Compound Library;Targeted Diversity Library;

Related Small Molecules:4E2RCat;CMLD012612;Rocaglamide;CMLD012072;eIF4A3-IN-6;4EGI-1;GCN2-IN-1;eIF4A3-IN-1;ML291;EIF2α activator 2;eIF4A3-IN-5;rel-Zotatifin;CMLD012073;eIF4A3-IN-8;eIF4E-IN-2;eIF4A3-IN-2;ATPγS tetralithium salt;eIF4A3-IN-4;GCN2-IN-6;Episilvestrol;CR-1-31-B;Rohinitib;eIF4E-IN-1;GCN2iB

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