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YW1128
CAS No. : 2131223-64-6
Biological Activity:YW1128 (compound 3a) is a potent Wnt/β-Catenin inhibitor. YW1128 induces the proteasome degradation of β-catenin and subsequent inhibits the Wnt/β-catenin signaling in cells. YW1128 significantly decreases hepatic lipid accumulation. YW1128 improves glucose tolerance of high fat diet-fed mice without noticeable toxicity. YW1128 down regulates the genes involved in the glucose and fatty acid anabolism.
Research Area:Metabolic Disease
Targets:Wnt|β-catenin
Related Small Molecules:Wnt/β-catenin agonist 1;ARUK3001185;Gallocyanine chloride;Fz7-21;NRX-252114;Foxy-5 TFA;Wnt/β-catenin agonist 4;JW74;IQ 1;Heparan Sulfate;CDK8-IN-11 hydrochloride;ETC-159;(E)-Ferulic acid-d3;Laduviglusib (GMP);NRX-252262;Toxoflavin;KY-05009;HLY78;Wnt-C59;Wogonin;NCB-0846;KY-02327;CCT031374 hydrobromide;β-catenin-IN-4;Echinacoside;JW67;IWP-4;Triptonide;Prodigiosin
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