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Ro 90-7501

CAS No. : 293762-45-5

Biological Activity：Ro 90-7501 is an amyloid β₄₂ (Aβ₄₂) fibril assembly inhibitor that reduces Aβ₄₂-induced cytotoxicity (EC₅₀ of 2 μM). Ro 90-7501 inhibits ATM phosphorylation and DNA repair. RO 90-7501 selectively enhances toll-like receptor 3 (TLR3) and RIG-I-like receptor (RLR) ligand-induced IFN-β gene expression and antiviral response^[2]. Ro 90-7501 also inhibits protein phosphatase 5 (PP5) in a TPR-dependent manner^[3]. Ro 90-7501 has significant radiosensitizing effects on cervical cancer cells^[4].

Research Area：Cancer|Neurological Disease

Targets：Amyloid-β|Phosphatase|ATM/ATR|Apoptosis

Related Small Molecules:Physalin A;Bomedemstat ditosylate;β-Amyloid (13-27);Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Saikosaponin C;ATR-IN-16;BJE6-106;Dinaciclib;GNF362;Ecteinascidin 770;ATR-IN-4;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5

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