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K-975
CAS No. : 2563855-03-6
Biological Activity：K-975 is a potent, selective and orally active TEAD inhibitor, with a strong inhibitory effect against protein-protein interactions between YAP1/TAZ and TEAD. K-975 covalently binds to Cys359 located in the palmitate-binding pocket of TEAD via an acrylamide structure. K-975 exhibits antitumor activity on malignant pleural mesothelioma.
Research Area：Cancer
Targets：YAP
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Orally Active Compound Library;Transcription Factor-Targeted Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:YAP-TEAD-IN-1;YAP-TEAD-IN-2;TT-10;MSC-4106;VT107;AICAR;Super-TDU;GA-017;Super-TDU (1-31) (TFA);TDI-011536;YAP/TAZ inhibitor-2;TED-347;TEAD-IN-3;ML-7 hydrochloride;Lats-IN-1;TEAD-IN-2;MYF-01-37;YAP/TAZ inhibitor-1;Cytochalasin D;PY-60;VT103
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