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Semagacestat
CAS No. : 425386-60-3
Biological Activity：Semagacestat is a γ-secretase inhibitor, inhibits β-amyloid (Aβ42), Aβ38 and Aβ40 with IC50s of 10.9, 12 and 12.1 nM, respectively; also inhibits Notch signaling with IC50 of 14.1 nM. Semagacestat can be used for the research of alzheimer’s disease.
Research Area：Neurological Disease
Targets：Notch|γ-secretase|Amyloid-β
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Neuronal Signaling Compound Library;Stem Cell Signaling Compound Library;Wnt/Hedgehog/Notch Compound Library;Clinical Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Anti-COVID-19 Compound Library;Anti-Alzheimer’s Disease Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Neurodegenerative Disease-related Compound Library;Angiogenesis-Related Compound Library;Transcription Factor-Targeted Library;Targeted Diversity Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Cancer Stem Cells Compound Library;
Related Small Molecules:β-Amyloid (13-27);γ-Secretase modulator 4;ELN318463;Saikosaponin C;ZLDI-8;β-Amyloid (1-42), (rat/mouse) (TFA);β-Amyloid (12-28) (TFA);BuChE-IN-5;Ginsenoside Rg1;MDR-1339;Crenigacestat;Aβ42-IN-1 free base;β-Amyloid (11-22);Fosciclopirox;FLI-06;20(S)-Ginsenoside Rg3;β-Amyloid (31-35);Aβ-IN-1;Qingyangshengenin B;JNJ-40418677;gamma-secretase modulator 3;HDAC6-IN-6;β-Amyloid (1-37) (human);CGP52411;Astrophloxine;γ-Secretase modulator 11 hydrochloride;γ-Secretase modulator 12
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