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BI-3406
CAS No. : 2230836-55-0
Biological Activity：BI-3406 (compound I-6) is an orally active, highly potent and selective inhibitor of the interaction between KRAS and Son of Sevenless 1 (SOS1) with an IC50 of 6 nM. BI-3406 potently reduces the formation of GTP-loaded KRAS, and inhibits MAPK pathway signaling. BI-3406 has anticancer activity[2].
Research Area：Cancer
Targets：p38 MAPK|Ras
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;MAPK Compound Library;Anti-Cancer Compound Library;Covalent Screening Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Ferroptosis Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Glutamine Metabolism Compound Library;Anti-Lung Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Neurodegenerative Disease-related Compound Library;Anti-Obesity Compound Library;Angiogenesis-Related Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:Deltarasin hydrochloride;ZINC09659342;SB-747651A dihydrochloride;Dehydrocorydaline;KRAS G12C inhibitor 56;CCG-232601;KRAS G12D inhibitor 14;SKF-86002 dihydrochloride;1A-116;KRAS G12D inhibitor 10;KRAS G12C inhibitor 20;KRAS G12C inhibitor 24;RM-018;KRAS G12C inhibitor 14;Pexmetinib;APS6-45;6H05;SB 242235;KRpep-2d TFA;KRAS G12C inhibitor 33;TA-01;KRAS G12C inhibitor 53;K-Ras-IN-1;KRAS G12C inhibitor 41;KRAS G12C inhibitor 26;KRAS G12C inhibitor 16;KRAS inhibitor-11;Anti-inflammatory agent 7;SOS1-IN-13
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