For research use only. We do not sell to patients.
PD-L1-IN-1
Biological Activity：PD-L1-IN-1 is a potent PD-L1 inhibitor with an IC50 of 115 nM. PD-L1-IN-1 strongly binds with the PD-L1 protein and challenged it in a co-culture of PD-L1 expressing cancer cells (PC9 and HCC827 cells) and peripheral blood mononuclear cells enhanced antitumor immune activity of the latter. PD-L1-IN-1 significantly increased interferon γ release and apoptotic induction of cancer cells, with low cytotoxicity in healthy cells.
Research Area：Cancer
Targets：PD-1/PD-L1
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Small Molecule Immuno-Oncology Compound Library;Anti-Breast Cancer Compound Library;Anti-Lung Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Liver Cancer Compound Library ;Anti-Colorectal Cancer Compound Library ;Protein-protein Interaction Inhibitor Library;
Related Small Molecules:PD-1/PD-L1-IN-15;PD-1/PD-L1-IN 5 TFA;PD-1/PD-L1-IN-25;PD-1/PD-L1-IN-18;PD-1/PD-L1-IN-22;Toripalimab;PD-1/PD-L1-IN-23;PD-1-IN-24;Evixapodlin;PD-1/PD-L1-IN-28;Onvatilimab;BMS-1001 hydrochloride;PD-1-IN-20;AUNP-12;BMSpep-57 hydrochloride;PD-1-IN-17;Anti-Mouse PD-L1 Antibody;ARB-272572;INCB086550;N2S2-CBMBC;Sintilimab;PD-1/PD-L1-IN 3;PD-1/PD-L1-IN-27;PD-1/PD-L1-IN-13;D18;N-deacetylated BMS-202;Human PD-L1 inhibitor III;Envafolimab
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Structurally and synthetically diverse biologically active compounds；
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