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3-Methylthienyl-carbonyl-JNJ-7706621

CAS No. : 443798-09-2

Biological Activity：3-Methylthienyl-carbonyl-JNJ-7706621 is a potent and selective inhibitor of cyclin-dependent kinase (CDK), with IC₅₀s of 6.4 nM and 2 nM for CDK1/cyclin B and CDK2/cyclin A, respectively. 3-Methylthienyl-carbonyl-JNJ-7706621 also shows potent inhibition of GSK-3 (IC₅₀=0.041 μM) and modest potency against CDK4, VEGF-R2, and FGF-R2 (IC₅₀=0.11, 0.13, 0.22 μM, respectively). 3-Methylthienyl-carbonyl-JNJ-7706621 can be used for the research of cancer.

Research Area：Cancer

Targets：CDK|VEGFR|GSK-3|FGFR

Related Small Molecules:(Z)-FeCP-oxindole;DB0614;TCS2002;Dinaciclib;VEGFR-2-IN-24;AR-A014418;BMS-690514;SNS-032;CC-671;PROTAC VEGFR-2 degrader-2;(E/Z)-Zotiraciclib;CDK1-IN-4;Henatinib;CCT-251921;BS-181;Samuraciclib hydrochloride hydrate;PI3K/VEGFR2-IN-1;T025;Flavopiridol;CDK8-IN-3;CDK9-IN-12;Ferulic acid-13C3;FLT3/CDK4-IN-1;GFB-12811;GSK 3 Inhibitor IX

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