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Oroxylin A

CAS No. : 480-11-5

Biological Activity：Oroxylin A is a natural active flavonoid with strong anticancer effects.
IC50 value:
Target:
In vitro: Oroxylin A suppressed the MDM2-mediated degradation of p53 via downregulating MDM2 transcription in wt-p53 cancer cells [1]. Oroxylin A remarkably reduced the generation of lactate and glucose uptake under hypoxia in HepG2 cells, inhibited HIF-1α expression and its stability [2]. Oroxylin A promotes superoxide dismutase (SOD2) gene expression through SIRT3-regulated DNA-binding activity of FOXO3a and increases the activity of SOD2 by promoting SIRT3-mediated deacetylation [3].
In vivo: Oroxylin A inhibited the tumor growth of nude mice-inoculated MCF-7 or HCT116 cells. The expression of MDM2 protein in tumor tissue was downregulated by oroxylin A as well [1].

Research Area：Cancer

Targets：Autophagy|HIF/HIF Prolyl-Hydroxylase|Virus Protease

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Related Small Molecules:SRPIN340;ZIKV-IN-4;TC-S 7009;Aminothiazole;CYP2C9/CYP2C19-IN-1;Glucosamine-13C hydrochloride;HIF1-IN-3;Prolyl Hydroxylase inhibitor 1;L-Lysine;Glucosamine-13C6,15N hydrochloride;HIF-PHD-IN-1;L-Lysine-13C6,15N2,d9 dihydrochloride;4E2RCat;AKBA;LW6;ESI-09;Tubacin;HIF-2α-IN-5;Lycorine;HIF-1/2α-IN-2;GEM-5;HIF-1/2α-IN-1;PCL 016;NGI-1;Roxadustat;(-)-α-Pinene;Daprodustat

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