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SC144
CAS No. : 895158-95-9
Biological Activity：SC144 is a first-in-class, orally active gp130 (IL6-beta) inhibitor. SC144 binds gp130, induces gp130 phosphorylation (S782) and deglycosylation, abrogates Stat3 phosphorylation and nuclear translocation, and further inhibits the expression of downstream target genes. SC144 shows potent inhibition of gp130 ligand-triggered signaling. SC144 induces apoptosis in human ovarian cancer cells.
Research Area：Cancer
Targets：Interleukin Related|Apoptosis
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Differentiation Inducing Compound Library;Orally Active Compound Library;Angiogenesis-Related Compound Library;Targeted Diversity Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;AX-024;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D;Ginsenoside F3
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