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K777
CAS No. : 233277-99-1
Biological Activity：K777 is a potent, orally active and irreversible cysteine protease inhibitor. K777 is also a potent CYP3A4 inhibitor with an IC50 of 60 nM and a selective CCR4 antagonist featuring the potent chemotaxis inhibition. K777 irreversibly inhibits Cruzain, the major cysteine protease of Trypansoma cruzi, and cathepsins B and L. K777 is a broad-spectrum antiviral by targeting cathepsin-mediated cell entry. K777 inhibits SARS-CoV and EBOV pseudovirus entry with IC50 values of 0.68 nM and 0.87 nM, respectively[2][3].
Research Area：Cancer|Infection
Targets：Cathepsin|CCR|Cytochrome P450
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Anti-Infection Compound Library;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Small Molecule Immuno-Oncology Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Antioxidant Compound Library;Oxygen Sensing Compound Library;Angiogenesis-Related Compound Library;Anti-Pulmonary Fibrosis Compound Library;Chemokine Compound Library;
Related Small Molecules:Calpeptin;SR9186;AMG-208;Cathepsin G Inhibitor I;CYP1B1-IN-1;CYP2C9/CYP2C19-IN-1;LMD-009;Hypericin;PF-04634817 succinate;Gly-Phe-β-naphthylamide;Galeterone;Ranitidine;Bergapten;Ginsenoside Rd;Z-FY-CHO;AS1810722;Balicatib;Vercirnon;Isoglycycoumarin;Polygalaxanthone III;Phenyltoloxamine;Ezutromid;Seviteronel;β-Apo-8′-carotenal;Diosmetin-d3
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