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PMX-53
CAS No. : 219639-75-5
Biological Activity：PMX-53 (3D53) is a synthetic peptidic and a potent and orally active complement C5a receptor (CD88) antagonist with an IC50 of 20 nM. PMX-53 is also a low-affinity MrgX2 agonist that stimulates MrgX2-mediated mast cell degranulation. PMX-53 specifically binds to C5aR1 and does not bind to the second C5aR (C5L2) and C3aR. PMX-53 has anti-inflammatory, anticancer and antiatherosclerotic effects[2][3][4][5][6].
Research Area：Cancer|Inflammation/Immunology|Cardiovascular Disease
Targets：Complement System
Related Screening Libraries:Bioactive Compound Library Plus;Immunology/Inflammation Compound Library;Anti-Cancer Compound Library;Macrocyclic Compound Library;Anti-Cardiovascular Disease Compound Library;Peptide Library;Cyclic Peptide Library;
Related Small Molecules:Cemdisiran;Pelecopan;PMX 205;EG00229;Factor B-IN-2;Tesidolumab;Factor B-IN-3;Avacincaptad pegol;Sutimlimab;FD-IN-1;NDT 9513727;Cyclosporin A;AMY-101;Lipoteichoic acid;Iptacopan;Entadamide-A-β-D-glucopyranoside;Compstatin TFA;C5aR-IN-2;BCX 1470;EG01377;TLQP-21;W-54011;Complement C5-IN-1;(Z)-Leukadherin-1
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