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Hck-IN-1

CAS No. : 1473404-51-1

Biological Activity：Hck-IN-1 (compound B9), a diphenylpyrazolo compound, is a selective Nef-dependent Hck inhibitor with IC₅₀s of 2.8 μM, >20 μM for Nef:Hck complex and Hck, respectively. Hck-IN-1 is a direct and wide HIV-1 Nef antagonists with an IC₅₀ of 100-300 nM for wild-type HIV-1 replication. Hck-IN-1 binds pocket residue Asn126 and has anti-retroviral activity.

Research Area：Infection

Targets：HIV|Src

Related Screening Libraries:Bioactive Compound Library Plus;Anti-Infection Compound Library;Kinase Inhibitor Library;Protein Tyrosine Kinase Compound Library;Antiviral Compound Library;Reprogramming Compound Library;Anti-Pancreatic Cancer Compound Library;Angiogenesis-Related Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;

Related Small Molecules:KB SRC 4;Tirbanibulin dihydrochloride;HIV-1 TAT (48-60);Seletracetam lithium;HIV-IN-2;Bafetinib;Triptonine B;p60c-src substrate II;FC131;Peritassine A;Caffeic acid-pYEEIE TFA;Flavopiridol;TAT (48-57);FGI-106 tetrahydrochloride;PP2;(Z)-9-Propenyladenine;Apabetalone;Decanoyl-RVKR-CMK TFA;ONX-0914 TFA;PP58

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