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NNC 55-0396
CAS No. : 357400-13-6
Biological Activity：NNC 55-0396, Mibefradil derivative, is a highly selective T-type calcium channel blocker; displays IC50 values of 6.8 and > 100 μM for inhibition of Cav3.1 T-type channels and HVA currents respectively in INS-1 cells.
IC50 value: 6.8 nM
Target: Cav3.1 T-type channel
NNC 55-0396 can be an essential tool in preventing human ovarian cancer cell proliferation as a result of its ability to inhibit the function of T-type Ca2+ channels. It is believed that NNC 55-0396 may functions by dissolving in or passing through the plasma membrane of cells.
Research Area：Cardiovascular Disease
Targets：Calcium Channel
Related Screening Libraries:Bioactive Compound Library Plus;Membrane Transporter/Ion Channel Compound Library;Neuronal Signaling Compound Library;Anti-Cardiovascular Disease Compound Library;Neuroprotective Compound Library;Calcium Channel Blocker Library;
Related Small Molecules:Benidipine hydrochloride;CaV1.3 antagonist-1;14-Deoxyandrographolide;(Rac)-MEM 1003;Glaucine;Efonidipine hydrochloride monoethanolate;L-Ascorbic acid sodium salt;Brompheniramine-d6 maleate;MRS 1523;Nilvadipine;Lercanidipine;CP-060;Anipamil-d25 hydrochloride;ISX-9;ω-Conotoxin MVIIC;Catharanthine;Thapsigargin;Tetrandrine;Ginsenoside Rd;Manidipine dihydrochloride;ω-Agatoxin IVA;AE0047 Hydrochloride;PDE1-IN-4
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