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JNJ-10229570
CAS No. : 524923-88-4
Biological Activity：JNJ-10229570 is an antagonist of melanocortin receptor 1 (MC1R) and melanocortin receptor 5 (MC5R), which inhibits sebaceous gland differentiation and the production of sebum-specific lipids. JNJ-10229570 inhibits the binding of 125I-NDP-α-MSH to cells expressing human MC1R and MC5R, with IC50 values of 270 nM and 200 nM, respectively.
Research Area：Endocrinology
Targets：Melanocortin Receptor
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;Endocrinology Compound Library;Targeted Diversity Library;
Related Small Molecules:Bremelanotide;MSG606 TFA;Resomelagon;Dersimelagon;Adrenocorticotropic Hormone (ACTH) (1-39), rat TFA;Terrein;γ1-MSH TFA;SNT-207707;PF-07258669;THIQ;ACTH (11-24) (acetate);JKC363 TFA;PG-931 TFA;[D-Trp8]-γ-MSH;MC-4R Agonist 1;ACTH (1-17);SNT-207858 free base;Lys-γ3-MSH(human);Nonapeptide-1;HS024 TFA;Adrenocorticotropic Hormone (ACTH) (4-10), human;SHU 9119;Adrenocorticotropic Hormone (ACTH) (1-39), human(TFA);(p-Iodo-Phe7)-ACTH (4-10)
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