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PYZD-4409

CAS No. : 423148-78-1

Biological Activity：PYZD-4409 is a specific inhibitor of the ubiquitin-activating enzyme UBA1 with an IC₅₀ of 20 μM (cell-free enzymatic assay). PYZD-4409 induces cell death in malignant cells and preferentially inhibits the clonogenic growth of primary acute myeloid leukemia cells.

Research Area：Cancer

Targets：E1/E2/E3 Enzyme

Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Oxygen Sensing Compound Library;Ubiquitination Compound Library;Endoplasmic Reticulum Stress Compound Library;Anti-Blood Cancer Compound Library;Anti-Liver Cancer Compound Library ;

Related Small Molecules:UBE2T/FANCL-IN-1;p53 and MDM2 proteins-interaction-inhibitor (racemic);Navtemadlin;MD-224;DI-1859;MX69;RG7112;Teslexivir;TRAF6 peptide;AM-8735;NAcM-OPT;RO-5963;SENP1-IN-3;Avadomide;M435-1279;MI-1061;HB007;Ubiquitination-IN-1;Milademetan;EN219;Nutlin-3;NSC624206;Hydrocotarnine;TAK-243;PYR-41;SZL P1-41;Siremadlin;BRD5529;SMIP004

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