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Amitriptyline-d3 hydrochloride

CAS No. : 342611-00-1

Biological Activity：Amitriptyline-d3 hydrochloride is the deuterium labeled Amitriptyline (hydrochloride). Amitriptyline hydrochloride is an inhibitor of serotonin reuptake transporter (SERT) and noradrenaline reuptake transporter (NET), with K_is of 3.45 nM and 13.3 nM for human SERT and NET, respectively. Amitriptyline hydrochloride also weakly binds to dopamine reuptake transporter (DAT) with a K_i of 2.58 μM. Amitriptyline hydrochloride also inhibits adrenergic, muscarinic, histamine and 5-HT receptors. Amitriptyline hydrochloride is a TrkA and TrkB receptors agonist with potent neurotrophic activity. Amitriptyline hydrochloride has antidepressant activity^[2]^[3].

Research Area：Neurological Disease

Related Small Molecules:VU0357017 hydrochloride;F 13714;Mosapride-d5;Lu AE98134;Todralazine;hTrkA-IN-1;TBPB;ARC 239 dihydrochloride;Imidafenacin;Zandatrigine;Sabcomeline;Nuciferine;Yohimbine;Tripelennamine;Glaucine;Veratridine;MK-6884;Salbutamol;Renzapride;Brompheniramine-d6 maleate

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