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KT109

CAS No. : 1402612-55-8

Biological Activity：KT109 is a potent and an isoform-selective inhibitor of diacylglycerol lipase-β (DAGLβ) with an IC₅₀ of 42 nM. KT109 has ~60-fold selectivity for DAGLβ over DAGLα. KT109 shows inhibitory activity against PLA2G7 (IC₅₀=1 µM). KT109 shows negligible activity against FAAH, MGLL, ABHD11, and cytosolic phospholipase A2 (cPLA2 or PLA2G4A). KT109 perturbs a lipid network involved in macrophage inflammatory responses and lowers 2-arachidonoylglycerol (2-AG), arachidonic acid and eicosanoids in mouse peritoneal macrophages.

Research Area：Metabolic Disease|Inflammation/Immunology

Targets：MAGL

Related Small Molecules:MAGL-IN-6;PF-06795071;JZL195;N-Arachidonyl maleimide;ML-226;JW 642;WWL123;Euphol;ABX-1431;JJKK 048;LEI-106;SAR629;DO-264;FAAH-IN-5;ABD957;JZP-361;MGL-IN-1;JZP-430;FAAH/MAGL-IN-2;Monoacylglycerol lipase inhibitor 1;KT182;SA57;FAAH/MAGL-IN-1;KML29;ML-211;MJN110;KT185;WWL70;MAGL-IN-5

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