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CMPD101

CAS No. : 865608-11-3

Biological Activity：CMPD101 is a potent, highly selective and membrane-permeable small-molecule inhibitor of GRK2/3 with IC₅₀ of 18 nM and 5.4 nM, respectively. CMPD101 exhibits less selectively against GRK1, GRK5, ROCK-2 and PKCα with IC₅₀s of 3.1 μM , 2.3 μM, 1.4 μM and 8.1 μM, respectively. CMPD101 can be used for the study of heart failure.

Research Area：Cardiovascular Disease

Targets：ROCK|PKC

Related Screening Libraries:Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Kinase Inhibitor Library;Stem Cell Signaling Compound Library;TGF-beta/Smad Compound Library;Anti-Aging Compound Library;Reprogramming Compound Library;Oxygen Sensing Compound Library;Anti-Cardiovascular Disease Compound Library;Cytoskeleton Compound Library;Anti-Pulmonary Fibrosis Compound Library;Cancer Stem Cells Compound Library;Coagulation and Anti-coagulation Compound Library;

Related Small Molecules:[Ala107]MBP(104-118) TFA;BJE6-106;Myelin Basic Protein;Staurosporine;PKC-iota inhibitor 1;Hypericin;Malantide;PKCiota-IN-2 formic;Ripasudil free base;PF-4950834;C8 Dihydroceramide;SC-9;DL-erythro-Dihydrosphingosine;Safingol;ROCK-IN-4;GSK-25;AT13148;LX7101;ZIP;Psychosine-d5;Y-27632 dihydrochloride;TPPB;RKI-1447;Enzastaurin

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