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L-685458
CAS No. : 292632-98-5
Biological Activity：L-685458 is a potent transition state analog (TSA) γ-secretase inhibitor (GSI). L-685458 inhibits amyloid β-protein precursor γ-secretase activity with IC50 of 17 nM, shows greater than 50-100-fold selectivity over other aspartyl proteases tested. L685458 inhibits γ-secretase-mediated cleavage of APP-C99 and Notch-100 with IC50s of 301.3 nM and 351.3 nM, respectively. L-685458 can be used for the research of alzheimer’s disease (AD) and cancers[2].
Research Area：Neurological Disease|Cancer
Targets：γ-secretase|Apoptosis
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Neuronal Signaling Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Anti-Aging Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Anti-Alzheimer’s Disease Compound Library;Neurodegenerative Disease-related Compound Library;Cancer Stem Cells Compound Library;
Related Small Molecules:Physalin A;Bomedemstat ditosylate;Enpp/Carbonic anhydrase-IN-1;γ-Secretase modulator 4;GK563;Calpeptin;Lobetyolin;ELN318463;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9;Bafetinib;Cyclovirobuxine D
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