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Glaucine-d6
Biological Activity：Glaucine-d6 (O,O-Dimethylisoboldine-d6) is the deuterium labeled Glaucine. Glaucine (O,O-Dimethylisoboldine) is an alkaloid isolated from Glaucium flavum Crantz with antitussive, bronchodilation and anti-inflammatory properties. Glaucine is a selective and orally active phosphodiesterase 4 (PDE4) inhibitor with Kis of 3.4 µM in human bronchus and polymorphonuclear leukocytes. Glaucine is also a non-selective α-adrenoceptor antagonist, a Ca2+ entry blocker, and a weak dopamine D1 and D2 receptor antagonist. Glaucine has antioxidative and antiviral activities[2][3].
Research Area：Infection|Inflammation/Immunology
Targets：Phosphodiesterase (PDE)|Dopamine Receptor|Adrenergic Receptor|Influenza Virus|Calcium Channel
Related Small Molecules:Senazodan hydrochloride;(E/Z)-HA155;Enpp/Carbonic anhydrase-IN-1;Alizapride hydrochloride;Benidipine hydrochloride;Thioproperazine;ATX inhibitor 22;CaV1.3 antagonist-1;14-Deoxyandrographolide;Carbazeran citrate;Todralazine;Bromopride-d3;ARC 239 dihydrochloride;Bay 60-7550;BC11-38;Nuciferine;Yohimbine;Curcumin;(R)-Camptothecin-d5;(Rac)-MEM 1003;Deltarasin hydrochloride;Glaucine
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