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Tolcapone-d4
CAS No. : 1246816-93-2
Biological Activity：Tolcapone-d4 (Ro 40-7592-d4) is the deuterium labeled Tolcapone. Tolcapone (Ro 40-7592) is a selective, orally active and powerful mixed (peripheral and central) COMT inhibitor with an IC50 of 773 nM in the liver. Tolcapone is also a potent inhibitor of α-syn and Aβ42 oligomerization and fibrillogenesis[2]. Tolcapone induces oxidative stress leading to apoptosis and inhibition of tumor growth in neuroblastoma[3].
Research Area：Cancer|Neurological Disease
Targets：COMT|Amyloid-β|Apoptosis
Related Small Molecules:Physalin A;Bomedemstat ditosylate;β-Amyloid (13-27);Enpp/Carbonic anhydrase-IN-1;GK563;Calpeptin;Lobetyolin;Nebicapone;Saikosaponin C;BJE6-106;Dinaciclib;Ecteinascidin 770;MDM2-p53-IN-15;AT9283;Staurosporine;SNS-032;C188-9;ZLDI-8;Topoisomerase I/II inhibitor 3;Xevinapant;Mangiferin;Cambinol;Antioxidant agent-5;Apoptosis inducer 9
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