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HS-276
CAS No. : 2767422-72-8
Biological Activity：HS-276 is an orally active, potent and highly selective TAK1 inhibitor, with a Ki of 2.5 nM. HS-276 shows significant inhibition of TAK1, CLK2, GCK, ULK2, MAP4K5, IRAK1, NUAK, CSNK1G2, CAMKKβ-1, and MLK1, with IC50 values of 8.25, 29, 33, 63, 125, 264, 270, 810, 1280, and 5585 nM, respectively. HS-276 can be used for rheumatoid arthritis (RA) research.
Research Area：Inflammation/Immunology
Targets：TNF Receptor|IRAK
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Kinase Inhibitor Library;Differentiation Inducing Compound Library;Pyroptosis Compound Library;Orally Active Compound Library;Angiogenesis-Related Compound Library;Antidepressant Compound Library;Anti-Prostate Cancer Compound Library;Anti-Pulmonary Fibrosis Compound Library;
Related Small Molecules:Akt/NF-κB/JNK-IN-1;AX-024;QNZ;Sinulatumolin E;IRAK4-IN-8;Edecesertib;Epobis;Mulberroside A;Sinulatumolin D;PDE4-IN-10;Ginsenoside Rc;TIC10;Teneliximab;Loganic acid 6′-O-β-D-glucoside;VGX-1027;IRAK4-IN-22;D-Trimannuronic acid;DCVC;Gamma-glutamylcysteine TFA;IRAK inhibitor 2;PROTAC IRAK4 degrader-3;Varlilumab;Sinulatumolin C;Thunbergol;Roquinimex;IRAK inhibitor 6;Semapimod tetrahydrochloride;GNE-2256
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