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CPI-455
CAS No. : 1628208-23-0
Biological Activity：CPI-455 is a specific, pan-KDM5 inhibitor with an IC50 of 10 nM for KDM5A. CPI-455 mediates KDM5 inhibition, elevates global levels of H3K4me3, and decreases the number of drug-tolerant persister cancer cells in multiple cancer cell line models treated with standard chemotherapy or targeted agents.
Research Area：Cancer
Targets：Histone Demethylase
Related Screening Libraries:Bioactive Compound Library Plus;Epigenetics Compound Library;Histone Modification Research Compound Library;Anti-Cancer Compound Library;Anti-Breast Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Targeted Diversity Library;
Related Small Molecules:Bomedemstat ditosylate;LSD1/ER-IN-1;PBIT;JQKD82;KDOAM-25 citrate;GSK-J1 lithium salt;S2116;LSD1-IN-16;TAK-418;NCGC00247743;DS17701585;KDM2B-IN-3;S2101;LSD1/2-IN-3;KDM5-IN-1;GSK467;S2157;PFI-90;FY-56;Eicosapentaenoic Acid;LSD1-IN-20;KDM5A-IN-1;Bizine;Procaine-d4 hydrochloride
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