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Laflunimus
CAS No. : 147076-36-6
Biological Activity：Laflunimus (HR325) is an immunosuppressive agent and an analogue of the Leflunomide-active metabolite A77 1726. Laflunimus is an orally active inhibitor of dihydroorotate dehydrogenase (DHODH). Laflunimus suppresses immunoglobulin (Ig) secretion, with IC50 values of 2.5 and 2 µM for IgM and IgG, respectively. Laflunimus also is a prostaglandin endoperoxide H synthase (PGHS) -1 and -2 inhibitor[2].
Research Area：Inflammation/Immunology
Targets：Dihydroorotate Dehydrogenase|DNA/RNA Synthesis|Prostaglandin Receptor
Related Screening Libraries:Covalent Screening Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;GPCR/G Protein Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;Anti-Aging Compound Library;Covalent Screening Library;Ferroptosis Compound Library;Angiogenesis-Related Compound Library;Mitochondria-Targeted Compound Library;
Related Small Molecules:Ametantrone;ddCTP trisodium;7-TFA-ap-7-Deaza-dA;P1788;Omidenepag isopropyl;DG-041;Thymidine-13C5,15N;NSC 617145;116-9e;DNA Gyrase-IN-5;DMT-2′-F-Bz-dA;6-Thio-2′-Deoxyguanosine;Antitumor agent-74;Risdiplam;8-Isoprostaglandin E2;BAY-6672;trans-Isoferulic acid;TH287 hydrochloride;GSK-269984A;KMN-80;Direct Black 38;PfDHODH-IN-2
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