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4-P-PDOT
CAS No. : 134865-74-0
Biological Activity：4-P-PDOT is a potent, selective and affinity Melatonin receptor (MT2) antagonist. 4-P-PDOT is >300-fold more selective for MT2 than MT1. 4-P-PDOT significantly counteracts Melatonin-mediated antioxidant effects (GSH/GSSG ratio, phospho-ERK, Nrf2 nuclear translocation, Nrf2 DNA-binding activity)[2][3][4].
Research Area：Neurological Disease
Targets：Melatonin Receptor
Related Screening Libraries:Bioactive Compound Library Plus;GPCR/G Protein Compound Library;Neuronal Signaling Compound Library;NF-κB Signaling Compound Library;Antioxidant Compound Library;Targeted Diversity Library;Human Metabolite Library;Cuproptosis Compound Library;
Related Small Molecules:Melatonin-d3;Antidepressant agent 3;6-Chloromelatonin;DH97;TIK-301;N-Acetyltryptamine;Luzindole;ACH-000143;Antidepressant agent 4;Agomelatin-d3;UCM 608;Piromelatine;8-M-PDOT;S26131;Melatonin-d7;2-Iodomelatonin
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