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Marein

CAS No. : 535-96-6

Biological Activity：Marein has the neuroprotective effect due to a reduction of damage to mitochondria function and activation of the AMPK signal pathway. Marein improves insulin resistance induced by high glucose in HepG2 cells through CaMKK/AMPK/GLUT1 to promote glucose uptake, through IRS/Akt/GSK-3β to increase glycogen synthesis, and through Akt/FoxO1 to decrease gluconeogenesis. Marein is a HDAC inhibitor with an IC₅₀ of 100 µM. Marein has beneficial antioxidative, antihypertensive, antihyperlipidemic and antidiabetic effects^[2]^[3].

Research Area：Metabolic Disease|Neurological Disease|Cardiovascular Disease

Targets：HDAC|AMPK

Related Screening Libraries:Natural Product Library Plus;Bioactive Compound Library Plus;Cell Cycle/DNA Damage Compound Library;Epigenetics Compound Library;Kinase Inhibitor Library;PI3K/Akt/mTOR Compound Library;Natural Product Library;Histone Modification Research Compound Library;Anti-Aging Compound Library;Antioxidant Compound Library;Reprogramming Compound Library;Anti-diabetic Compound Library;Glycoside Compound Library;Oxygen Sensing Compound Library;Anti-Cardiovascular Disease Compound Library;Phenols Library;Glycolysis Compound Library;Cytoskeleton Compound Library;Flavonoids Library;Neuroprotective Compound Library;Anti-Breast Cancer Compound Library;Anti-Pancreatic Cancer Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Anti-Obesity Compound Library;Transcription Factor-Targeted Library;Lipid Metabolism Compound Library ;Glucose Metabolism Compound Library;Anti-Liver Cancer Compound Library ;Plant-Sourced Natural Product Library;Osteogenesis Compound Library;

Related Small Molecules:AMPK activator 4;Pivanex;Crotonoside;MPT0B390;ZLN024;YLF-466D;RSC133;HDAC1/6-IN-1;HDAC/HSP90-IN-4;JPS014;HDAC-IN-4;BAY-3827;HDAC-IN-27;1-Alaninechlamydocin;3α-Hydroxymogrol;SKLB-23bb;Tacedinaline;HPOB;HDAC-IN-28;CG347B;Tubacin;HDAC10-IN-1;HDAC6-IN-6;Resminostat;Alteminostat;HDAC-IN-47;Ivaltinostat formic;HTH-01-015

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