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Androgen receptor antagonist 1

CAS No. : 1338812-36-4

Biological Activity：Androgen receptor antagonist 1 is an orally available full androgen receptor (AR) antagonist with an IC₅₀ of 59 nM. Androgen receptor antagonist 1 (Compound 6) can be used in the synthesis of PROTAC AR degraders, which results 24% and 47 % AR protein degradation in LNCaP cells at 1 μM and 10 μM, respectively^[2].

Research Area：Cancer

Targets：Androgen Receptor|Ligands for Target Protein for PROTAC

Related Screening Libraries:Bioactive Compound Library Plus;Anti-Cancer Compound Library;Transcription Factor-Targeted Library;Anti-Prostate Cancer Compound Library;Nuclear Receptor Compound Library;Target Protein Ligand Library;

Related Small Molecules:VPC-14449;AC-262536;BI-4464;GTx-007;PROTAC BRD4 ligand-2;PROTAC BRD9-binding moiety 1 hydrochloride;PROTAC IRAK4 ligand-1;Apcin-A;Linuron-d6;MI-136;Ipatasertib-NH2 dihydrochloride;VPC-13789;RD162;ARD-2585;PF-998425;SirReal1-O-propargyl;GSK-2881078;PD0325901-O-C2-dioxolane;CDK9-IN-10;PROTAC AR Degrader-4;TSPO ligand-1;RU 58841;SLF TFA

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