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2-Methoxyestradiol-d5

CAS No. : 358731-34-7

Biological Activity：2-Methoxyestradiol-d5 is the deuterium labeled 2-Hydroxyestradiol. 2-Methoxyestradiol (2-ME2), an orally active endogenous metabolite of 17β-estradiol (E2), is an apoptosis inducer and an angiogenesis inhibitor with potent antineoplastic activity. 2-Methoxyestradiol also destablize microtubules. 2-Methoxyestradio, also a potent superoxide dismutase (SOD) inhibitor and a ROS-generating agent, induces autophagy in the transformed cell line HEK293 and the cancer cell lines U87 and HeLa^{[2][3][4][5][6][7]}.

Targets：Autophagy|Reactive Oxygen Species|Microtubule/Tubulin|Endogenous Metabolite|Apoptosis

Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Physalin A;Nicotinamide N-oxide;3-Hydroxyglutaric acid-d5;DPPC-d62;SDMA-d6;Bomedemstat ditosylate;2-Mercaptobenzothiazole;Chitoheptaose heptahydrochloride;N-Acetyl-L-glutamic acid-d5;(3R,5S)-3-Hydroxy Cotinine-d3;Enpp/Carbonic anhydrase-IN-1;Biliverdin hydrochloride;GK563;Calpeptin;Lobetyolin;Tirbanibulin dihydrochloride;D-Glucose-13C,d1-3;2,3-Diaminopropionic acid hydrochloride;Docosanoic acid-d3;Choline-d6 chloride;Pregnenolone monosulfate sodium;25-Hydroxycholesterol-d6;N-Acetyl-D-cysteine

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