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RU.521
CAS No. : 2262452-06-0
Biological Activity：RU.521 (RU320521) is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor and inhibits cGAS-mediated interferon upregulation. RU.521 suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM. RU.521 reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).
Research Area：Metabolic Disease
Targets：Cyclic GMP-AMP Synthase
Related Screening Libraries:Bioactive Compound Library Plus; Immunology/Inflammation Compound Library;Chemical Probe Library;
Related Small Molecules:G140;PF-06928215;G150;IRAK4-IN-4
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