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ML786 dihydrochloride

CAS No. : 1237536-18-3

Biological Activity：ML786 dihydrochloride is a potent and orally bioavailable Raf inhibitor, with IC₅₀s of 2.1, 4.2, and 2.5 nM for ^V600EΔB-Raf, wt B-Raf, and C-Raf, respectively. ML786 dihydrochloride also inhibits Abl-1, DDR2, EPHA2, KDR, and RET (IC₅₀=<0.5, 7.0, 11, 6.2, 0.8 nM). ML786 dihydrochloride can be used for the research of cancers.

Research Area：Cancer

Targets：Discoidin Domain Receptor|Raf|VEGFR|Bcr-Abl|RET|Ephrin Receptor

Related Small Molecules:(Z)-FeCP-oxindole;JNK3 inhibitor-2;Avutometinib;VEGFR-2-IN-24;BMS-690514;AT9283;Bafetinib;PROTAC VEGFR-2 degrader-2;AZ 628;Pivanex;Henatinib;SNIPER(ABL)-039;PI3K/VEGFR2-IN-1;LDN-211904 oxalate;Flumatinib mesylate;IHMT-TRK-284;RET-IN-18;Hydroxytanshinone IIA;Chiauranib;Foretinib;ZM323881 hydrochloride;Zeteletinib;SNIPER(ABL)-049;Olverembatinib

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