For research use only. We do not sell to patients.

AMG 837

CAS No. : 865231-46-5

Biological Activity：AMG 837 is a potent GPR40 agonist(EC50=13 nM) with a superior pharmacokinetic profile and robust glucose-dependent stimulation of insulin secretion in rodents.
IC50 value: 13 nM (EC50) [1]
Target: GPR40 agonist
AMG 837 displayed the expected two-fold increase in potency on GPR4 (EC50 = 13 [±7] nM) compared to the racemic compound and its activity crossed over to the rat and mouse forms of GPR40 (EC50 = 23 and 13 nM, respectively). AMG 837 was found to be a partial agonist on GPR40 with maximal activity 85% of that shown by DHA under our standard assay conditions. AMG 837 is a highly potent stimulator of insulin secretion in MIN6 cells with an EC50 comparable to that seen in the aequorin Ca2+-flux assay. showed
no significant activity in cell-based assays against PPARα, δ, and γ. An external panel of 64 receptors also revealed no significant activity with the exception of weak inhibition (IC50 = 3 uM) on the a2-adrenergic receptor. Overall, AMG 837 was both highly potent
and selective in vitro.

Research Area：Metabolic Disease

Targets：Free Fatty Acid Receptor

Related Small Molecules:GW-1100;Grifolic acid;Ginsenoside Rb2;AP5;GPR40 Activator 1;AM-1638;DC260126;TUG-770;LY2881835;FFA1 agonist-1;GPR120 Agonist 3;AS2034178 free base;GPR40 Agonist 2;BMS-986118;AMG7703;Fasiglifam;MEDICA16;AR420626;AMG 837 sodium salt;Xelaglifam;TUG-1375;GPR120 Agonist 1;GPR40 agonist 5;TUG-424;GPR120 modulator 2;LY2922470;4-CMTB

Trending products：Recombinant Proteins  |  Bioactive Screening Libraries  |  Natural Products  |  Fluorescent Dye  |  PROTAC  |  Isotope-Labeled Compounds  |  Oligonucleotides

About Us:

• MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
• Structurally and synthetically diverse biologically active compounds；
•  roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
• We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
• Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；

Structurally and synthetically diverse biologically active compounds；

• Customized order volume ranging from milligrams to kilograms scale；

We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.