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α1A-AR Degrader 9c

Biological Activity：α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC₅₀ of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC₅₀ of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research.

Research Area：Cancer

Targets：Adrenergic Receptor|PROTACs

Related Small Molecules:PROTAC Sirt2 Degrader-1;DB0614;Todralazine;ARC 239 dihydrochloride;Yohimbine;PROTAC VEGFR-2 degrader-2;dTAGV-1-NEG;CCT367766 formic;Glaucine;Salbutamol;BI-167107;HDAC6 degrader-1;Talibegron hydrochloride;PROTAC Axl Degrader 2;PhosTAC7;MS98;Arotinolol;SR59230A;JPS014;PROTAC PARP1 degrader

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