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VRT-043198
CAS No. : 244133-31-1
Biological Activity：VRT-043198, the drug metabolite of VX-765 (Belnacasan), is a potent, selective and blood-brain barrier permeable inhibitor of interleukin-converting enzyme/caspase-1 subfamily caspases. VRT-043198 exhibits Ki values of 0.8 nM and 0.6 nM for ICE/caspase-1 and caspase-4, respectively.
Research Area：Inflammation/Immunology
Targets：Drug Metabolite|Caspase
Related Screening Libraries:Bioactive Compound Library Plus;Apoptosis Compound Library;Immunology/Inflammation Compound Library;Metabolism/Protease Compound Library;CNS-Penetrant Compound Library;Pyroptosis Compound Library;Drug Metabolite Library;Targeted Diversity Library;
Related Small Molecules:Nicotinamide N-oxide;4-Hydroxyphenylbutazone;Dehydrocorydaline;Ampyrone;Resveratrol-3-O-sulfate sodium;Sonidegib metabolite M48;Isonicotinic acid;Cycloguanil hydrochloride;Z-DEVD-AMC;Hydroxytanshinone IIA;Endoxifen;p-nitro-Pifithrin-α;ML132;L67;Fodipir;AKN-028 acetate;Regorafénib N-oxyde (M2)-13C,d3;AZ7550 Mesylate;AR-13324 M1 metabolite;Ossirene;Thyroxine sulfate;Netupitant metabolite Monohydroxy Netupitant;δ-Secretase inhibitor 11;Anticancer agent 63;Fenbufen-d9;(-)-(E)-Guggulsterone;Leukotriene D4;Desbutyl Lumefantrine;Penicillic acid;Sesamolin;(R)-3-Hydroxy Midostaurin
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