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Poloppin
CAS No. : 683808-78-8
Biological Activity：Poloppin is a potent, cell penetrant inhibitor of the mitotic Polo-like kinase (PLK) (IC50=26.9 μM) and prevents the protein-protein interaction via the Polo-box domain (PBD) (Kd= 29.5 μM). Poloppin selectively kills cells expressing mutant KRAS, enhancing death in mitosis. Poloppin is used for the study of KRAS-mutant cancers as single agents, or in combination with c-MET inhibitors.
Research Area：Cancer
Targets：Autophagy|Polo-like Kinase (PLK)
Related Small Molecules:TAK-960;Rigosertib sodium;Centrinone;HMN-176;(1E)-CFI-400437 dihydrochloride;Poloxin;PLK1-IN-2;PLK1-IN-4;MLN0905;TC-S 7005;PLK4-IN-3;SBE13 Hydrochloride;CFI-400437;Plogosertib;Volasertib;3MB-PP1;Wortmannin;PLK1/BRD4-IN-1;Poloxime;Cyclapolin 9;ON1231320;BI 2536
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