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MK-0752
CAS No. : 471905-41-6
Biological Activity：MK-0752 is a potent, orally active and specific γ-secretase inhibitor, showing dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells. MK-0752 crosses the blood-brain barrier. MK-0752 reduces newly generated CNS Aβ in vivo[2].
Research Area：Neurological Disease|Cancer
Targets：γ-secretase
Related Screening Libraries:Drug Repurposing Compound Library Plus;Clinical Compound Library Plus;Bioactive Compound Library Plus;Neuronal Signaling Compound Library;Stem Cell Signaling Compound Library;Anti-Cancer Compound Library;Clinical Compound Library;Anti-Aging Compound Library;Drug Repurposing Compound Library;Differentiation Inducing Compound Library;Reprogramming Compound Library;Orally Active Compound Library;Anti-Pancreatic Cancer Compound Library;Neurodegenerative Disease-related Compound Library;Targeted Diversity Library;Cancer Stem Cells Compound Library;
Related Small Molecules:γ-Secretase modulator 4;ELN318463;Crenigacestat;Aβ42-IN-1 free base;Fosciclopirox;JNJ-40418677;gamma-secretase modulator 3;γ-Secretase modulator 11 hydrochloride;γ-Secretase modulator 12;Aβ42-IN-2;DAPT (GMP);BPN-15606;LY-411575 (isomer 3);BMS 433796;YO-01027 (GMP);BI-1408;Nirogacestat dihydrobromide;gamma-secretase modulator 1 hydrochloride;MRK-560;Semagacestat;Begacestat;GSM-1;Compound E;L-685458
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