For research use only. We do not sell to patients.
(S,R)-GSK321
CAS No. : 1816272-18-0
Biological Activity：(S,R)-WT IDH1 Inhibitor 2 (GSK321) is a potent, selective mutant IDH1 inhibitor with IC50 values of 2.9, 3.8, 4.6 and 46 nM for R132G, R132C, R132H and WT IDH1, respectively, and >100-fold selectivity over IDH2. (S,R)-WT IDH1 Inhibitor 2 induces decrease in intracellular 2-HG, abrogation of the myeloid differentiation block and induction of granulocytic differentiation at the level of leukemic blasts and more immature stem-like cells. (S,R)-WT IDH1 Inhibitor 2 can be used for research of acute myeloid leukemia (AML) and other cancers.
Research Area：Cancer
Targets：Isocitrate Dehydrogenase (IDH)
Related Screening Libraries:Bioactive Compound Library Plus;Metabolism/Protease Compound Library;Anti-Cancer Compound Library;Glutamine Metabolism Compound Library;Anti-Blood Cancer Compound Library;Anti-Cancer Metabolism Compound Library;Mitochondria-Targeted Compound Library;Glucose Metabolism Compound Library;
Related Small Molecules:mIDH1-IN-1;Enasidenib mesylate;AGI-12026;IDH1 Inhibitor 2;DS-1001b;BAY-1436032;Mutant IDH1-IN-1;(R,S)-Ivosidenib;AGI-5198;IDH-C227;IDH1 Inhibitor 1;AGI-6780;Mutant IDH1-IN-6;Olutasidenib;IDH-305;IDH1 Inhibitor 3;IDH2R140Q-IN-1;Vorasidenib;IDH889;IDH1 Inhibitor 5;Mutant IDH1 inhibitor;Mutant IDH1-IN-2;Mutant IDH1-IN-4;GSK864
Trending products：Recombinant Proteins | Bioactive Screening Libraries | Natural Products | Fluorescent Dye | PROTAC | Isotope-Labeled Compounds | Oligonucleotides
About Us:
- MedChemExpress (MCE) offers a wide range of high-quality research chemicals and biochemicals (novel life-science reagents, reference compounds and natural compounds) for scientific use；
- Structurally and synthetically diverse biologically active compounds；
- roduct quality is the key to our success and we take pride in offering only the highest-grade products.；
- We provide HNMR, LC-MS, HPLC, stability testing and activity assays of our products to clients.；
- Product identity, quality, purity and activity are assured by our robust quality control programs and procedures.；
- Customized order volume ranging from milligrams to kilograms scale；
Structurally and synthetically diverse biologically active compounds；
We provide customer-oriented services. To explore more, please contact us at [email protected]. Our team will gladly assist you.
