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Simvastatin acid

CAS No. : 121009-77-6

Biological Activity：Simvastatin acid (Tenivastatin), a hydrolysate of Simvastatin (HY-17502), is a HMG-CoA reductase (HMGCR) inhibitor. Simvastatin acid reduces Indoxyl sulfate-mediated reactive oxygen species (ROS) production in human cardiomyocytes. Simvastatin acid can also modulates OATP3A1 expression in cardiomyocytes and HEK293 cells transfected with the OATP3A1 gene^[2].

Research Area：Cancer|Cardiovascular Disease

Targets：Reactive Oxygen Species|HMG-CoA Reductase (HMGCR)

Related Small Molecules:D-α-Hydroxyglutaric acid disodium;Chitoheptaose heptahydrochloride;N-Acetyl-D-cysteine;Topoisomerase I/II inhibitor 3;CYPMPO;Antioxidant agent-5;ROS-ERS inducer 1;Glucosamine-13C hydrochloride;L-Ascorbic acid sodium salt;D-Isofloridoside;L-Carnitine-d3 hydrochloride;Licochalcone D;β-Amyrin acetate;SR12813;Euparin;RH-EDA;1,3-Dicaffeoylquinic acid;Antitumor agent-68;Echinocystic acid;Glucosamine-13C6,15N hydrochloride;PI3Kα-IN-8;Maresin 1-d5;Ecabet sodium;Ethoxyquin;Eugenol-d3

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