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(3S,5R)-Rosuvastatin

CAS No. : 1242184-42-4

Biological Activity：(3S,5R)-Rosuvastatin is the (3S,5R)-enantiomer of Rosuvastatin. Rosuvastatin is a competitive HMG-CoA reductase inhibitor with an IC₅₀ of 11 nM. Rosuvastatin potently blocks human ether-a-go-go related gene (hERG) current with an IC₅₀ of 195 nM^[2]. Rosuvastatin reduces the expression of the mature hERG and the interaction of heat shock protein 70 (Hsp70) with the hERG protein. Rosuvastatin is very effective in lowering low-density lipoprotein (LDL) cholesterol, triglycerides, and C-reactive protein levels^[3].

Research Area：Metabolic Disease|Cardiovascular Disease

Targets：Autophagy|Potassium Channel|HMG-CoA Reductase (HMGCR)

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