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TAK-659
CAS No. : 1312691-33-0
Biological Activity：TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. TAK-659 induces cell death in tumor cells but not in nontumor cells, and with potential for the treatment of chronic lymphocytic leukemia (CLL)[2][3][4].
Research Area：Cancer
Targets：FLT3|Syk
Related Small Molecules:AT9283;(E/Z)-Zotiraciclib;Crotonoside;FLT3-IN-13;PDGFRα/FLT3-ITD-IN-2;FLT3/CDK4-IN-1;Lanraplenib monosuccinate;HP1142;ENMD-2076 Tartrate;ATH686;AZD2932;AKN-028 acetate;FLT3-IN-3;UNC2025 hydrochloride;Tandutinib;OXSI-2;Gilteritinib-d8;PF 477736;(R)-3-Hydroxy Midostaurin;BSc5371;SYK/JAK-IN-1;PRT062607 Hydrochloride;OTS447;MNS;PDGFRα/FLT3-ITD-IN-1;TAK-659 hydrochloride;FLT3-IN-4
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