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Lenalidomide-C4-NH2 hydrochloride

Biological Activity：Lenalidomide-C4-NH2 hydrochloride is the Lenalidomide-based Cereblon ligand used in the recruitment of CRBN protein. Lenalidomide-C4-NH2 hydrochloride can be connected to the ligand for protein by a linker to form PROTAC (Compound 24), which has IC₅₀s of 0.98 nM and 13.7 nM in inhibition of RS4;11 and MOLM-13 acute leukemia cell lines growth, respectively.

Research Area：Cancer

Targets：E3 Ligase Ligand-Linker Conjugates

Related Small Molecules:cIAP1 Ligand-Linker Conjugates 6 hydrochloride;(S,R,S)-AHPC-Me-C10-NH2;cIAP1 Ligand-Linker Conjugates 2;Glutarimide-Isoindolinone-NH-PEG3-COOH;cIAP1 Ligand-Linker Conjugates 4;(S,R,S)-AHPC-Me-C7 ester;(S,R,S)-AHPC-C2-PEG4-N3;cIAP1 Ligand-Linker Conjugates 5;cIAP1 Ligand-Linker Conjugates 7;cIAP1 Ligand-Linker Conjugates 16;(S,R,S)-AHPC-C8-NH2 hydrochloride;cIAP1 Ligand-Linker Conjugates 8;(S,R,S)-AHPC-PEG4-NH2;VHL Ligand-Linker Conjugates 15;VH032-PEG3-acetylene;(S,R,S)-AHPC-PEG2-NH2 dihydrochloride;VH032-PEG5-C6-Cl;(S,R,S)-AHPC-Me-C5-COOH

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